Recent regulatory testing programs have been designed to evaluate whether a chemical has the potential to interact with the endocrine system and could cause adverse effects. Some endocrine pathways are highly conserved among vertebrates, providing a potential to extrapolate data generated for one vertebrate taxonomic group to others (i.e., biological read-across). To assess the potential for biological read-across, we reviewed tools and approaches that support species extrapolation for fish, amphibians, birds, and reptiles. For each of the estrogen, androgen, thyroid, and steroidogenesis (EATS) pathways, we considered the pathway conservation across species and the responses of endocrine sensitive endpoints. Available data show a high degree of confidence in the conservation of the hypothalamus-pituitary-gonadal axis between fish and mammals and the hypothalamus-pituitary-thyroid axis between amphibians and mammals. Comparatively, there is less empirical evidence for the conservation of other EATS pathways between other taxonomic groups, but this may be due to limited data. While more information on sensitive pathways and endpoints would be useful, current developments in the use of molecular target sequencing similarity tools and thoughtful application of the adverse outcome pathway concept show promise for further advancement of read-across approaches for testing EATS pathways in vertebrate ecological receptors. This article is protected by copyright. All rights reserved.

中文翻译：

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脊椎动物生态受体内分泌相关效应测试中跨读潜力的批判性评论。

最近的监管测试计划旨在评估化学物质是否有可能与内分泌系统相互作用并可能造成不良影响。一些内分泌途径在脊椎动物中高度保守，提供了将一个脊椎动物分类群生成的数据外推到其他分类群的数据的潜力（即生物读取）。为了评估生物学交叉阅读的潜力，我们回顾了支持鱼类、两栖动物、鸟类和爬行动物物种推断的工具和方法。对于每条雌激素、雄激素、甲状腺和类固醇生成 (EATS) 途径，我们考虑了跨物种的途径保守性以及内分泌敏感终点的反应。现有数据显示，人们对鱼类和哺乳动物之间的下丘脑-垂体-性腺轴以及两栖动物和哺乳动物之间的下丘脑-垂体-甲状腺轴的保护具有高度的信心。相比之下，其他分类群之间其他 EATS 途径的保守性的经验证据较少，但这可能是由于数据有限。虽然有关敏感途径和终点的更多信息将是有用的，但目前在分子靶标测序相似性工具的使用和不良结果途径概念的深思熟虑应用方面的发展表明，有希望进一步推进用于测试脊椎动物生态受体中 EATS 途径的跨读方法。本文受版权保护。版权所有。