PURPOSE The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) and their relationship with clinical features and disease activity using spectral domain optical coherence tomography (SD-OCT) and Angio-OCT technology. METHODS Eighteen patients and control subjects underwent a complete eye examination, OCT, and Angio-OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2, and L3) below the choriocapillary. RESULTS The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared with 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E-07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared with healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E-07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168). CONCLUSIONS Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared with healthy subjects.

中文翻译：

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使用SD-OCT和Angio-OCT对甲状腺相关性眼病（TAO）患者的脉络膜厚度和脉络膜血管血流进行评估。

目的本研究的目的是使用光谱域光学相干断层扫描技术（SD-OCT）和扫描能谱法评估甲状腺相关性眼病（TAO）患者脉络膜厚度和脉络膜血管血流的变化及其与临床特征和疾病活动的关系。 Angio-OCT技术。方法对18名患者和对照组进行了全面的眼部检查，OCT和Angio-OCT。我们还获得了脉络膜毛细血管下方3个不同的连续水平（L1，L2和L3）的血管造影照片。结果在TAO患者中，小凹下脉络膜明显厚于对照眼（285.6275±32.5μm，分别为135.89±19.8μm，p = 0.0089）。TAO组的相关性分析显示脉络膜厚度与EUGOGO临床评分之间存在显着相关性（r = 0.84，p = 8.44032E-07）。与健康受试者相比，患有TAO的受试者的脉络膜毛细血管的血管流量明显减少（49.78±4.5对53.36±1.07； p = 2.5105E-07），而在TAO受试者中，较深层L3的血管血流高于健康受试者（46.9±20.23和41.475±3.06; p = 0.01168）。结论与健康受试者相比，TAO患者的小凹下脉络膜厚度和脉络膜血流显着不同。