Since the human genome was sequenced, extensive effort has been placed into mapping the role of genes in the onset of disease. It was expected that we would be able to explain the cause of disease and understand the genetic basis of health. However, we have found that while the genetic contribution to individual diseases varies, non-genetic factors have far greater attributable risks, often in the range of 80–90%. The dominance of non-genetic components highlights the importance of the environment to chronic disease risks and has led to the advent of the nascent field of exposome science. Genetic susceptibility can alter the initiation of lung diseases, but environmental triggers are vital determinants. There is an urgent need to study the exposome – the sum total of environmental exposures – to understand the aetiology of lung diseases. http://bit.ly/2YG5XpP

中文翻译：

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基因-环境相互作用在肺病中的作用：对暴露体的迫切需要

自从人类基因组被测序以来，人们已经付出了广泛的努力来绘制基因在疾病发作中的作用。预计我们将能够解释疾病的原因并了解健康的遗传基础。然而，我们发现虽然遗传对个体疾病的贡献各不相同，但非遗传因素的可归因风险要大得多，通常在 80-90% 的范围内。非遗传成分的主导地位突出了环境对慢性病风险的重要性，并导致了暴露组科学这一新兴领域的出现。遗传易感性可以改变肺部疾病的发生，但环境触发因素是重要的决定因素。迫切需要研究暴露组——环境暴露的总和——以了解肺部疾病的病因。网址：