Airway hyperresponsiveness (AHR) is associated with an increased mortality risk among males [1] and chronic obstructive pulmonary disease (COPD) patients [2]. However, this association is largely based on cross-sectional studies using a single measurement of AHR to predict mortality; inherently ignoring the longitudinal variability of AHR. AHR is variable regardless of disease or medication status, and is linked with changes in smoking habits, seasonal variations and exposure to pollutants [3–5]. Considering this, it remains unclear how changes in AHR affect mortality, specifically from causes such as COPD, cardiovascular disease (CVD) and cancer. Airway hyperresponsiveness displayed on multiple occasions independently leads to a higher risk of COPD death http://bit.ly/363Wfkg

中文翻译：

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气道高反应性和 COPD 死亡率的纵向变化

气道高反应性 (AHR) 与男性 [1] 和慢性阻塞性肺病 (COPD) 患者的死亡风险增加有关 [2]。然而，这种关联主要基于使用单一 AHR 测量来预测死亡率的横断面研究；本质上忽略了 AHR 的纵向可变性。无论疾病或药物状态如何，AHR 都是可变的，并且与吸烟习惯的变化、季节性变化和接触污染物有关 [3-5]。考虑到这一点，尚不清楚 AHR 的变化如何影响死亡率，特别是 COPD、心血管疾病 (CVD) 和癌症等原因引起的死亡率。多次独立显示气道高反应性导致 COPD 死亡风险更高 http://bit.ly/363Wfkg