Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice.,European Journal of Immunology

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Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-03-12 , DOI: 10.1002/eji.201948391
Priyangi A Malaviarachchi ₁ , Miguel A B Mercado ₁ , Stephen J McSorley ₂ , Lin-Xi Li ₁

Affiliation

The obligate intracellular bacterium Chlamydia trachomatis causes the most prevalent bacterial sexually transmitted infection worldwide. CD4 T cells play a central role in the protective immunity against Chlamydia female reproductive tract (FRT) infection, while B cells are thought to be dispensable for resolution of primary Chlamydia infection in mouse models. We recently reported an unexpected requirement of B cells in local Chlamydia-specific CD4 T-cell priming and bacterial containment within the FRT. Here, we sought to tackle the precise effector function of B cells during Chlamydia primary infection. Using mixed bone marrow chimeras that lack B-cell-dependent Ag presentation (MHCIIB - / - ) or devoid of circulating antibodies (AID-/- × μS-/- ), we show that Chlamydia-specific CD4 T-cell expansion does not rely on Ag presentation by B cells. Importantly, we demonstrate that antibody, but not B-cell-dependent Ag presentation, is required for preventing systemic bacterial dissemination following Chlamydia FRT infection.

中文翻译：

抗体，而不是B细胞依赖性抗原呈递，在预防小鼠衣原体系统性传播中起着至关重要的作用。

专一的细胞内细菌沙眼衣原体引起全世界最普遍的细菌性传播感染。CD4 T细胞在抵抗衣原体女性生殖道（FRT）感染的保护性免疫中起着核心作用，而B细胞被认为对于解决小鼠模型中的原发性衣原体感染是必不可少的。我们最近报道了FRT中局部衣原体特异性CD4 T细胞启动和细菌遏制中B细胞的意外需求。在这里，我们试图解决衣原体原发感染期间B细胞的精确效应子功能。使用缺乏B细胞依赖性Ag表现（MHCIIB-/-）或缺乏循环抗体（AID-/-×μS-/-）的混合骨髓嵌合体，我们显示衣原体特异性CD4 T细胞扩增没有依靠B细胞的银呈递。

更新日期：2020-03-12

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