With the recent advances in our understanding of the function and biology of the lymphatic vascular system, it is clear that the lymphatic system plays an integral role in physiology, and in pathological settings, may contribute to either enhance or repress inflammation and disease progression. Inflammation is central to both acute and chronic rejection in the context of solid organ transplantation, and emerging evidence suggests the lymphatic system plays a key role in shaping outcomes. The goals of this review are to highlight and contextualize the roles of lymphatic vessels and lymphangiogenesis in immunobiology, the impact immunosuppressive therapies have on the lymphatic system and emerging evidence of organ‐specific heterogeneity of lymphatic vessels in the context of solid organ transplantation.

中文翻译：

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实体器官移植和免疫生物学中的淋巴管。

随着我们对淋巴血管系统的功能和生物学的理解的最新进展，很明显淋巴系统在生理学和病理学环境中起着不可或缺的作用，可能有助于增强或抑制炎症和疾病进展。在实体器官移植的情况下，炎症是急性和慢性排斥反应的核心，新出现的证据表明淋巴系统在影响结果方面起着关键作用。本综述的目的是强调淋巴管和淋巴管生成在免疫生物学中的作用，并将其背景化，免疫抑制疗法对淋巴系统的影响以及实体器官移植背景下淋巴管器官特异性异质性的新证据。