Schwann cells: Rescuers of central demyelination.,Glia

当前位置： X-MOL 学术 › Glia › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Schwann cells: Rescuers of central demyelination.
Glia ( IF 5.4 ) Pub Date : 2020-02-06 , DOI: 10.1002/glia.23788
Beatriz Garcia-Diaz _{1,

2,

3} , Anne Baron-Van Evercooren _{2,

3}

Affiliation

The presence of peripheral myelinating cells in the central nervous system (CNS) has gained the neurobiologist attention over the years. Despite the confirmed presence of Schwann cells in the CNS in pathological conditions, and the long list of their beneficial effects on central remyelination, the cues that impede or allow Schwann cells to successfully conquer and remyelinate central axons remain partially undiscovered. A better knowledge of these factors stands out as crucial to foresee a rational therapeutic approach for the use of Schwann cells in CNS repair. Here, we review the diverse origins of Schwann cells into the CNS, both peripheral and central, as well as the CNS components that inhibit Schwann survival and migration into the central parenchyma. Namely, we analyze the astrocyte‐ and the myelin‐derived components that restrict Schwann cells into the CNS. Finally, we highlight the unveiled mode of invasion of these peripheral cells through the central environment, using blood vessels as scaffolds to pave their ways toward demyelinated lesions. In short, this review presents the so far uncovered knowledge of this complex CNS‐peripheral nervous system (PNS) relationship.

中文翻译：

雪旺氏细胞：中枢脱髓鞘的拯救者。

多年来，中枢神经系统 (CNS) 中外周髓鞘细胞的存在引起了神经生物学家的关注。尽管已证实在病理条件下中枢神经系统中存在雪旺细胞，并且它们对中枢髓鞘再生的有益影响一长串，但阻碍或允许雪旺细胞成功征服和髓鞘再生中枢轴突的线索仍有部分未被发现。更好地了解这些因素对于预见在 CNS 修复中使用雪旺细胞的合理治疗方法至关重要。在这里，我们回顾了雪旺细胞进入中枢神经系统的不同起源，包括外周和中枢，以及抑制雪旺细胞存活和迁移到中央薄壁组织的 CNS 成分。即，我们分析了限制雪旺氏细胞进入 CNS 的星形胶质细胞和髓鞘衍生成分。最后，我们强调了这些外周细胞通过中央环境侵入的公开模式，使用血管作为支架为脱髓鞘病变铺平了道路。简而言之，这篇综述介绍了迄今为止尚未发现的关于这种复杂的 CNS 与外周神经系统 (PNS) 关系的知识。

更新日期：2020-02-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11