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Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S-Equol and Its Consequences for ERα Activation.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-02-25 , DOI: 10.1002/mnfr.201900912
Qianrui Wang 1 , Bert Spenkelink 1 , Rungnapa Boonpawa 2 , Ivonne M C M Rietjens 1 , Karsten Beekmann 1
Affiliation  

To predict gut microbial metabolism of xenobiotics and the resulting plasma concentrations of metabolites formed, an in vitro–in silico‐based testing strategy is developed using the isoflavone daidzein and its gut microbial metabolite S‐equol as model compounds.

中文翻译:

使用基于生理学的动力学模型来预测大鼠肠道微生物从异黄酮黄豆苷元到 S-雌马酚的代谢及其对 ERα 激活的影响。

为了预测异生物质的肠道微生物代谢以及由此形成的代谢物的血浆浓度,使用异黄酮大豆苷元及其肠道微生物代谢物S-牛马酚作为模型化合物,开发了一种基于体外计算机模拟的测试策略。
更新日期:2020-02-25
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