Patient-derived organoids can recapitulate parental tumor heterogeneity. In a recent study in Cell, Jacob et al. cultivated glioblastoma organoids (GBOs) to mimic tumor heterogeneity and chimeric antigen receptor (CAR)-T cell immunotherapy, applied it for xenograft establishment and drug testing, and generated a biobank for the timely start of post-operation therapy.

中文翻译：

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类器官：准备用于胶质母细胞瘤精准医​​学的平台？

患者来源的类器官可以概括亲本肿瘤的异质性。在Cell的最新研究中，Jacob等人。培养的胶质母细胞瘤类器官（GBO）可以模拟肿瘤异质性和嵌合抗原受体（CAR）-T细胞免疫疗法，将其用于异种移植物建立和药物测试，并产生了一个生物库，以便及时启动术后治疗。