A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure. Integration-free episomal vector-mediated reprogramming was used for the generation of this iPSC line. The established iPSC line was found to express pluripotency markers, exhibit a differentiation potential in vitro, as well as display a normal karyotype. We further identified that this iPSC line contained a mutation in collagen type IV (COL4A2, R131M), which may serve as a useful tool for the disease modeling of aortic dissection.

中文翻译：

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从患有主动脉夹层的患者中产生人诱导的多能干细胞系（WMUi001-A）。

从47岁供血主动脉夹层且血压正常的人的主动脉组织中产生了人诱导的多能干细胞（hiPSC）系（WMUi001-A）。无整合游离型载体介导的重编程用于此iPSC系的生成。发现已建立的iPSC系表达多能性标记，在体外表现出分化潜能，并显示出正常的核型。我们进一步确定，该iPSC品系包含IV型胶原蛋白（COL4A2，R131M）中的突变，这可能是用于主动脉夹层疾病建模的有用工具。