BACKGROUND Inadequate fluid removal or high water intake leads to overhydration, which results in malnutrition. The aim of the present study was to evaluate the effects of volume status on body composition in incident peritoneal dialysis (PD) patients. METHODS All incident PD patients who survived ≥1 year after PD initiation were considered eligible. A total of 366 incident PD patients were finally included and divided into three tertiles according to the time-averaged-edema index (TA-EI). The body composition parameters measured using bioimpedance analysis included the EI, fat mass index (FMI, kg/m2), and appendicular muscle mass index (AMMI, kg/m2). dFMI and dAMMI were defined as delta values for each variable. The cutoff value for sarcopenia (SP) was defined as previously reported. Patients with AMMI below the cutoff values were defined as having SP. RESULTS The number of participants in the low, middle, and high tertiles was 126, 100, and 140, respectively. A high volume status was associated with high solute clearance, albumin loss, and glucose absorption through the peritoneal membrane, which led to high dialysate glucose. In addition, volume status was inversely associated with increases in AMMI, but was not associated with changes in FMI. SP as a categorical variable was positively associated with a high volume status. On subgroup analyses, TA-EI had the greatest negative correlation coefficients for dAMMI. CONCLUSION Overhydration in PD patients was associated with decrease in muscle mass indices and the development of SP.

中文翻译：

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体液状态对入射腹膜透析患者身体成分的影响。

背景技术流体去除不足或高水摄入量会导致水合作用过度，从而导致营养不良。本研究的目的是评估腹膜透析（PD）患者体位状态对身体成分的影响。方法所有入选PD后≥1年的PD患者均符合条件。最终总共纳入了366名PD患者，根据时间平均水肿指数（TA-EI）分为三分位数。使用生物阻抗分析测量的身体成分参数包括EI，脂肪质量指数（FMI，kg / m2）和阑尾肌肉质量指数（AMMI，kg / m2）。dFMI和dAMMI被定义为每个变量的增量值。肌肉减少症（SP）的临界值定义为先前报道的值。AMMI低于临界值的患者被定义为患有SP。结果低，中，高三分位数的参与者人数分别为126、100和140。高体积状态与高溶质清除率，白蛋白损失和通过腹膜的葡萄糖吸收有关，这导致高透析液葡萄糖。此外，音量状态与AMMI的增加呈反比关系，但与FMI的变化无关。SP作为一个分类变量与高音量状态呈正相关。在亚组分析中，TA-EI对dAMMI的负相关系数最大。结论PD患者水合作用与肌肉质量指数降低和SP发展有关。和140。高体积状态与高溶质清除率，白蛋白损失和通过腹膜的葡萄糖吸收有关，这导致高透析液葡萄糖。此外，音量状态与AMMI的增加呈反比关系，但与FMI的变化无关。SP作为一个分类变量与高音量状态呈正相关。在亚组分析中，TA-EI对dAMMI的负相关系数最大。结论PD患者水合作用与肌肉质量指数降低和SP发展有关。和140。高体积状态与高溶质清除率，白蛋白损失和通过腹膜的葡萄糖吸收有关，这导致高透析液葡萄糖。此外，音量状态与AMMI的增加呈反比关系，但与FMI的变化无关。SP作为一个分类变量与高音量状态呈正相关。在亚组分析中，TA-EI对dAMMI的负相关系数最大。结论PD患者水合作用与肌肉质量指数降低和SP发展有关。音量状态与AMMI的增加呈反比关系，但与FMI的变化无关。SP作为一个分类变量与高音量状态呈正相关。在亚组分析中，TA-EI对dAMMI的负相关系数最大。结论PD患者水合作用与肌肉质量指数降低和SP发展有关。音量状态与AMMI的增加呈反比关系，但与FMI的变化无关。SP作为一个分类变量与高音量状态呈正相关。在亚组分析中，TA-EI对dAMMI的负相关系数最大。结论PD患者水合作用与肌肉质量指数降低和SP发展有关。