A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity.,The Journal of Antibiotics

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A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2020-02-05 , DOI: 10.1038/s41429-020-0281-x
Christopher Sarmales-Murga ₁ , Fumito Akaoka ₁ , Michio Sato ₁ , Jun Takanishi ₁ , Takashi Mino ₂ , Noriyuki Miyoshi ₃ , Kenji Watanabe ₁

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Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC50 of 17.3 µM. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).

中文翻译：

从真菌Chaetomium globosum分离出的一类新的二聚体产物：化学结构和生物学活性的评估。

Chaetomium globosum是一种丝状真菌，我们以前从中分离出了一系列有趣的天然产物。在这里，我们从C. globosum的培养物中分离出了以前未知的天然产物。通过光谱和晶体学表征，我们将该化合物确定为一种新的二聚氮杂苯甲酮类产品，我们将其称为耳蜗酮J（1）。此外，我们对天然产物的生物学活性的研究确定1对人宫颈癌HeLa细胞具有细胞毒性，IC50为17.3 µM。最后，根据我们先前对紧密相关化合物耳蜗内酯A（2）的生物合成的研究，提出了一种可行的1的生物合成机理。

更新日期：2020-02-05

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