A copper/pyridinebisoxazoline-catalyzed desymmetrization of prochiral 2-sila-1,3-propanediols with benzoyl chlorides has been described. The catalytic system allowed the construction of optically active silymethanol derivatives containing a quaternary siliconstereogenic center in good to high yields and moderate to good enantiomeric excesses.

中文翻译：

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铜催化的手性四取代硅二醇的对映选择性脱对称：进入光学活性的硅立体异构的甲硅烷基甲醇的途径

已经描述了铜/吡啶双恶唑啉催化的手性2-sila-1,3-丙二醇与苯甲酰氯的脱对称化。该催化体系允许以良好至高收率和中度至良好对映体过量构建具有季硅固相中心的旋光性硅基甲醇衍生物。