People living with HIV (PWH) are at higher risk for cardiovascular disease (CVD) and stroke in comparison to their non-infected counterparts. The ABCS (aspirin-blood pressure control-cholesterol control-smoking cessation) reduce atherosclerotic (ASCVD) risk in the general population, but little is known regarding strategies for promoting the ABCS among PWH. Guided by the Consolidated Framework for Implementation Research (CFIR), we designed multilevel implementation strategies that target PWH and their clinicians to promote appropriate use of the ABCS based on a 10-year estimated ASCVD risk. Implementation strategies include patient coaching, automated texting, peer phone support, academic detailing and audit and feedback for the patient's clinician. We are evaluating implementation through a stepped wedge cluster randomized trial based on the Reach-Effectiveness-Adoption-Maintenance/Qualitative-Evaluation-for-Systematic-Translation (RE-AIM/QuEST) mixed methods framework that integrates quantitative and qualitative assessments. The primary outcome is change in ASCVD risk. Findings will have important implications regarding strategies for reducing ASCVD risk among PWH.

中文翻译：

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规程文件：逐步楔形聚类随机试验将ABCS转化为优化HIV感染者的心血管护理。

与未感染艾滋病毒的人相比，艾滋病毒感染者（PWH）患心血管疾病（CVD）和中风的风险更高。ABCS（阿司匹林血压控制-胆固醇控制-戒烟）可降低一般人群的动脉粥样硬化（ASCVD）风险，但对于在PWH中推广ABCS的策略知之甚少。在实施研究综合框架（CFIR）的指导下，我们基于10年估计的ASCVD风险，设计了针对PWH及其临床医生的多级实施策略，以促进适当使用ABCS。实施策略包括患者指导，自动发短信，对等电话支持，学术详细资料以及对患者临床医生的审核和反馈。我们正在根据结合有效量化/定性评估/系统翻译定性评估（RE-AIM / QuEST）混合方法框架的逐步楔形聚类随机试验评估实施情况。主要结果是ASCVD风险的改变。研究结果将对降低PWH中ASCVD风险的策略具有重要意义。