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Synthesis of new selenium-containing analogs of phenozan acid
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2019-12-01 , DOI: 10.1007/s11172-019-2715-9
S. V. Kholshin , S. E. Yagunov , N. V. Kandalintseva , A. E. Prosenko

Selenium-containing analogs of phenozan acid, [3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propylseleno]ethanoic and 3-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propylseleno]propanoic acids, were synthesized from bis-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]diselenide. The possibility of functionalization of the obtained compounds via the esterification and preparation of potassium salts was demonstrated. According to the in silico evaluation of acute toxicity towards rats, the synthesized compounds are low toxic and non-toxic substances.

中文翻译:

吩赞酸的新型含硒类似物的合成

酚酸、[3-(3,5-二叔丁基-4-羟基苯基)-丙基硒基]乙醇和3-[3-(3,5-二-叔丁基-4-羟基苯基)的含硒类似物)丙基硒基]丙酸由双-[3-(3,5-二-叔丁基-4-羟基苯基)丙基]二硒化物合成。证明了通过酯化和制备钾盐对所得化合物进行官能化的可能性。根据对大鼠急性毒性的计算机模拟评价,合成的化合物为低毒和无毒物质。
更新日期:2019-12-01
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