Abstract

The N-vinyl-2-pyrrolidone-grafted-carboxymethylcellulose was synthesised by employing a free radical polymerization method in an N₂ atmosphere. It was found that 0.661 g concentration of monomer was sufficient to afford the maximum grafting parameters viz. % grafting (%G), % efficiency (%E) % Add on (%A) % and conversion (%C), but these grafting indicators showed a decreasing trend with increasing the concentration of monomer from 0.661 g to 0.993 g. The prepared graft copolymer was characterized by FT-IR, ¹H NMR, TGA/DTG, SEM, GPC and X-ray diffraction (XRD) analysis. The hybrid of the grafted CMC with the sodium alginate was prepared and used to study the loading and release of levofloxacin drug, about 70% loading of levofloxacin was observed and its 80% release was observed in phosphate buffer solution (PBS) at pH 7.4 & 37 °C in 30 h.

中文翻译：

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N-乙烯基-2-吡咯烷酮在羧甲基纤维素上的接枝共聚及其在水溶性左氧氟沙星控释中的应用

摘要

通过在N ₂气氛中采用自由基聚合法来合成N-乙烯基-2-吡咯烷酮接枝的羧甲基纤维素。发现0.661g单体浓度足以提供最大接枝参数，即。％接枝（％G），％效率（％E）％添加（％A）％和转化率（％C），但是这些接枝指示剂显示出随着单体浓度从0.661g增加到0.993g而降低的趋势。制备的接枝共聚物经FT-IR表征，¹1 H NMR，TGA / DTG，SEM，GPC和X射线衍射（XRD）分析。制备了接枝CMC与藻酸钠的杂种，并用于研究左氧氟沙星药物的负载和释放，观察到约70％的左氧氟沙星负载，在pH 7.4的磷酸盐缓冲液（PBS）中观察到其80％的释放在30小时内达到37°C。