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Pine needle hexane extract promote cell cycle arrest and premature senescence via p27KIP1 upregulation gastric cancer cells.
Food Science and Biotechnology ( IF 2.4 ) Pub Date : 2020-02-05 , DOI: 10.1007/s10068-019-00730-5
Woong Kim 1 , Cheolwoo Park 2 , Jaeyoung Park 3 , Hyeonsook Cheong 3 , Seok-Jun Kim 3, 4
Affiliation  

Pinus densiflora sieb. et zucc.(pine needle) is a traditional medicine used in several East Asian countries. However, the efficacy of pine needle has rarely been reported. In this study showed that the anti-proliferative effects and the mechanisms of hexane layer of pine needle MeOH extract (PNH) on gastric cancer cells. At first, PNH inhibited the proliferation of gastric cancer cells in a dose-dependent manner. Moreover, PNH treatment induced G1 phase cell cycle arrest through the increased p27KIP1 expression and decreased cyclin dependent kinase (CDKs) activity. Furthermore, PNH treatment induced premature senescence without oncogenic stress, through the expression of p27KIP1 and Skp2. Taken together, these results showed that PNH inhibited gastric cancer cell proliferation through the induction of G1-cell cycle arrest and premature senescence via induced p27KIP1 expression, as controlled by Skp2 reduction. Also, PNH could be a candidate for anti-gastric cancer treatment and may be useful in the development of anti-gastric cancer drugs.



中文翻译:

松针己烷提取物通过上调胃癌细胞p27KIP1促进细胞周期停滞和过早衰老。

松树 et zucc。(松针)是东亚几个国家/地区使用的传统药物。但是,很少报道松针的功效。这项研究表明,松针甲醇提取物(PNH)的己烷层对胃癌细胞具有抗增殖作用及其机理。首先,PNH以剂量依赖的方式抑制胃癌细胞的增殖。此外,PNH治疗通过增加p27 KIP1表达和降低细胞周期蛋白依赖性激酶(CDKs)活性诱导G1期细胞周期停滞。此外,PNH处理通过表达p27 KIP1诱导早衰而无致癌性应激和Skp2。综上所述,这些结果表明,PNH通过诱导G1细胞周期停滞和诱导p27 KIP1表达而导致早衰,抑制了胃癌细胞的增殖,这受Skp2还原的控制。而且,PNH可能是抗胃癌治疗的候选药物,可能在抗胃癌药物的开发中有用。

更新日期:2020-02-05
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