A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A (1), along with three known compounds, xylarinol A (2), nectriapyrone (3), and asperisocoumarin A (4), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1, 3, and 4 showed weak Vibrio harveyi inhibition with MIC values ranging from 16 to 64 μg/mL, whereas 2 was found to be inactive.

中文翻译：

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一种来自海绵衍生真菌曲霉属的新型抗菌氯化氨基酸衍生物。LS53

分离出一种名为 aspergamide A (1) 的具有稀有 3-chloro-4-hydroxyphenyl 单元的新型氯化氨基酸衍生物，以及三种已知化合物 xylarinol A (2)、nectriapyrone (3) 和 asperisocoumarin A (4)来自海绵来源的真菌 Aspergillus sp。LS53。它们的结构是通过结合详细的光谱分析和文献数据确定的。化合物 1、3 和 4 显示出弱的哈维弧菌抑制作用，MIC 值范围为 16 至 64 μg/mL，而发现 2 无活性。