BACKGROUND Silver diamine fluoride (SDF) solution gains increasing popularity in arresting dentine caries in clinical practice. The aim of this systematic review was to summarize the findings from laboratory studies on the influence of SDF application on the bond strength of dentine to various adhesives and to glass ionomer cements (GICs). METHODS Two independent reviewers conducted a literature search in the databases Medline, Ovid, PubMed and Web of Science until 15th August 2019 using the search keywords ['bond strength'] AND ['silver diamine fluoride' OR 'silver diammine fluoride' OR 'SDF' OR 'silver fluoride' OR 'diamine silver fluoride']. Articles investigating the effect of SDF application on the bond strength of dentine to various adhesives and to GICs were included in this review. Information on how SDF application influenced the bond strength was extracted from the included articles. Besides, related information, e.g. test method of bond strength, concentration and brand of SDF, type of adhesive system and GIC, testing dental substrate, protocol of specimen preparation, and failure mode was also reviewed. RESULTS A total of 13 articles were included in this review, with 8 and 6 studies investigating the effect of SDF application on the bond strength of dentine to various adhesives and to GICs, respectively. Sound dentine as well as demineralized dentine created by chemical methods, e.g. immersing in a demineralizing solution, was commonly adopted as the testing dental substrate. The microtensile bond strength (mTBS) test was the predominant method employed. However, the bond strength values had large variations among studies, ranging from <10 to 162 Mpa. Regarding the bond strength to different adhesives, 4 studies indicated that SDF application followed by rinsing with water had no significant influence. However, another 4 studies reported reduced bond strength after SDF application. Regarding the bond strength to GICs, 4 studies concluded that SDF application had no adverse impact on the bond strength. CONCLUSIONS No solid conclusion can be drawn on the effect of SDF application on the bond strength of dentine to adhesives and to GICs due to the high degree of variation of the included studies.

中文翻译：

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氟化二胺银溶液对牙本质与胶粘剂和玻璃离聚物胶粘剂粘合强度的影响：系统综述。

背景技术氟化二胺氟化银（SDF）溶液在临床实践中在抑制牙本质龋中越来越受欢迎。本系统综述的目的是总结实验室研究的结果，这些研究涉及SDF的应用对牙本质与各种粘合剂和玻璃离聚物水泥（GIC）粘结强度的影响。方法直到2019年8月15日，两名独立的评论者使用检索关键字['bond strength']和['silver diamine chloride'或'silver diammine chloride'或'SDF”在Medline，Ovid，PubMed和Web of Science数据库中进行文献检索'或'氟化银'或'二胺氟化银']。这篇文章探讨了SDF的应用对牙本质与各种粘合剂和GIC的粘合强度的影响的文章。从随附的文章中提取了有关SDF应用如何影响粘结强度的信息。此外，还回顾了相关信息，例如粘合强度的测试方法，SDF的浓度和品牌，粘合剂体系和GIC的类型，牙科基体的测试，标本制备的协议以及失效模式。结果本评价共纳入13篇文章，其中8篇和6篇研究分别研究了SDF施加对牙本质与各种粘合剂和GIC的粘合强度的影响。通过化学方法（例如浸入去矿物质溶液中）产生的健全的牙本质以及去矿物质的牙本质通常被用作测试牙齿基质。微拉伸粘合强度（mTBS）测试是主要采用的方法。然而，研究之间的结合强度值差异很大，范围从<10到162 Mpa。关于与不同胶粘剂的粘合强度，有4项研究表明SDF的施涂，然后用水冲洗没有显着影响。但是，另外4项研究报道了SDF施用后粘合强度降低。关于与GIC的粘结强度，有4项研究得出结论，使用SDF对粘结强度没有不利影响。结论由于所纳入研究的高度变异性，因此无法得出关于SDF施加对牙本质与胶粘剂和GIC粘合强度的影响的可靠结论。另有4项研究报道了使用SDF后粘合强度降低。关于与GIC的粘结强度，有4项研究得出结论，使用SDF对粘结强度没有不利影响。结论由于所纳入研究的高度差异性，因此无法确定SDF施用对牙本质与胶粘剂和GIC的粘合强度的影响。另有4项研究报道了使用SDF后粘合强度降低。关于与GIC的粘结强度，有4项研究得出结论，使用SDF对粘结强度没有不利影响。结论由于所纳入研究的高度差异性，因此无法确定SDF施用对牙本质与胶粘剂和GIC的粘合强度的影响。