BACKGROUND This study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted. METHODS Patients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed. Irrigation was done with ozonized (group 1) or double distilled water (group 2). The type of irrigation and the side to be operated were randomized. Neither the patients nor the operator or evaluator were aware of the irrigation solution. Pain, oedema and trismus were evaluated at baseline, 24-h, 48-h, 72-h and 7-days after treatment. The data were evaluated by Friedman, Wilcoxon, Mann-Whitney tests, and size effect. RESULTS It was included 8 men and 12 women, with a mean age of 20.9y.o. The initial pain mean was 7.94 (±12.81) (group 1) and 5.50 (±9.12) (group 2) (p > 0,05). There was a statistically significant reduction of pain, oedema and trismus in intragroup analysis (p < 0.05). There was no statistically significant difference (p > 0.05) when comparing the oedema and trismus between groups. The size effect ranged from small (0.23) to large (1.29). CONCLUSIONS It was concluded that ozonized water was compatible as irrigation method, not inferior to double distilled water, and had satisfactory effects on management of pain, oedema and trismus after surgical removal of the third molar. TRIAL REGISTRATION This clinical trial was registered in ClinicalTrials.gov NCT03501225 on April 18, 2018.

中文翻译：

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臭氧水对受影响的第三磨牙手术过程中疼痛，水肿和三头肌的影响：一项随机，三盲临床试验。

背景技术本研究旨在评估臭氧化水与双重蒸馏水相比，对第三磨牙下颌手术造成的疼痛，水肿和三头肌的疗效。进行了一项随机三盲试验。方法纳入佩尔-格雷戈里（Pell-Gregory）第三磨牙II-B级的患者，并进行手术摘除。用臭氧化水（第1组）或双蒸馏水（第2组）进行灌溉。灌溉类型和要操作的一侧是随机的。患者，操作人员或评估人员都没有意识到冲洗液。在治疗后的基线，24小时，48小时，72小时和7天评估疼痛，​​浮肿和三头肌。数据通过Friedman，Wilcoxon，Mann-Whitney检验和尺寸效应进行评估。结果该研究包括8名男性和12名女性，平均年龄为20.9岁 初始疼痛平均值为7.94（±12.81）（第1组）和5.50（±9.12）（第2组）（p> 0.05）。组内分析显示，疼痛，水肿和三头肌的减少有统计学意义（p <0.05）。比较两组之间的水肿和三头肌时，无统计学差异（p> 0.05）。大小影响范围从小（0.23）到大（1.29）。结论得出结论，臭氧水可作为冲洗方法兼容，不逊于双倍蒸馏水，并且在手术去除第三磨牙后对疼痛，水肿和三头肌的处理具有令人满意的效果。试验注册该临床试验已于2018年4月18日在ClinicalTrials.gov NCT03501225中进行了注册。组内分析显示，疼痛，水肿和三头肌的减少有统计学意义（p <0.05）。比较两组之间的水肿和三头肌时，无统计学差异（p> 0.05）。大小影响范围从小（0.23）到大（1.29）。结论得出结论，臭氧水可作为冲洗方法兼容，不逊于双倍蒸馏水，并且在手术去除第三磨牙后对疼痛，水肿和三头肌的处理具有令人满意的效果。试验注册该临床试验已于2018年4月18日在ClinicalTrials.gov NCT03501225中进行了注册。组内分析显示，疼痛，水肿和三头肌的减少有统计学意义（p <0.05）。比较两组之间的水肿和三头肌时，无统计学差异（p> 0.05）。大小影响范围从小（0.23）到大（1.29）。结论得出结论，臭氧水可作为冲洗方法兼容，不逊于双倍蒸馏水，并且在手术去除第三磨牙后对疼痛，水肿和三头肌的处理具有令人满意的效果。试验注册该临床试验已于2018年4月18日在ClinicalTrials.gov NCT03501225中进行了注册。23）到大（1.29）。结论得出结论，臭氧水可作为冲洗方法兼容，不逊于双倍蒸馏水，并且在手术去除第三磨牙后对疼痛，水肿和三头肌的处理具有令人满意的效果。试验注册该临床试验已于2018年4月18日在ClinicalTrials.gov NCT03501225中进行了注册。23）到大（1.29）。结论得出结论，臭氧水可作为冲洗方法兼容，不逊于双倍蒸馏水，并且在手术去除第三磨牙后对疼痛，水肿和三头肌的处理具有令人满意的效果。试验注册该临床试验已于2018年4月18日在ClinicalTrials.gov NCT03501225中进行了注册。