OBJECTIVES The aim of our study was to examine the role of low density lipoprotein (LDL)-subfractions in individuals with the atherogenic and non-atherogenic phenotype and the gender differences in lipoprotein subfractions including small dense LDL (sdLDL) and small high density lipoprotein (sHDL) subfractions representing the most atherogenic lipoprotein subfractions. DESIGN & METHODS 35 persons in the atherogenic group (AG) (with sdLDL3-7 subfractions ≥6 mg/dl) and 104 individuals in the non-atherogenic group (NAG) (sdLDL3-7 subfractions <6 mg/dl) were included in our study. To analyze plasma lipoprotein subfractions, a polyacrylamide gel electrophoresis-the Lipoprint system was used. RESULTS Males compared to females in the AG had significantly higher levels of atherogenic lipoprotein subfractions such as HDL8, HDL9 and HDL10. All participants in AG had significantly lower levels of intermediate density lipoprotein IDL-A than those in NAG but significantly higher levels of IDL-B and IDL-C. Males in the AG compared to NAG had significantly lower levels of LDL1 and higher levels of LDL2 and LDL3-7 subfractions. In the NAG LDL2 positively correlated with sHDL subfractions while in the AG with the large HDL subfraction. CONCLUSION Results of our study demonstrate more atherogenic profile in males compared to females and a double role of LDL2 subfraction in the atherogenic process depending on the phenotype (atherogenic/non-atherogenic) of individuals.

中文翻译：

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动脉粥样硬化和非动脉粥样硬化表型的LDL和HDL亚部分的性别差异。

目的本研究的目的是研究低密度脂蛋白（LDL）亚型在具有动脉粥样硬化和非动脉粥样硬化表型的个体中的作用以及脂蛋白亚型包括小密度LDL（sdLDL）和小高密度脂蛋白（ sHDL）亚型代表最致动脉粥样硬化脂蛋白亚型。设计与方法包括35例动脉粥样硬化组（AG）（sdLDL3-7亚组份≥6mg / dl）和104例非动脉粥样硬化组（NAG）（sdLDL3-7亚组份<6 mg / dl）纳入我们的研究。为了分析血浆脂蛋白亚组分，使用了聚丙烯酰胺凝胶电泳-Lipoprint系统。结果在AG中，男性比女性具有更高的动脉粥样硬化脂蛋白亚组分水平，例如HDL8，HDL9和HDL10。与NAG相比，所有AG参与者的中密度脂蛋白IDL-A水平均显着降低，但IDL-B和IDL-C的水平显着较高。与NAG相比，AG中的男性的LDL1水平明显较低，而LDL2和LDL3-7亚组分水平较高。在NAG中，LDL2与sHDL子分数呈正相关，而在AG中，HDL子分数大。结论我们的研究结果表明，与女性相比，男性具有更多的动脉粥样硬化特征，并且LDL2亚组分在动脉粥样硬化过程中具有双重作用，具体取决于个体的表型（动脉粥样硬化/非动脉粥样硬化）。与NAG相比，AG中的男性的LDL1水平明显较低，而LDL2和LDL3-7亚组分水平较高。在NAG中，LDL2与sHDL子分数呈正相关，而在AG中，HDL子分数大。结论我们的研究结果表明，与女性相比，男性具有更多的动脉粥样硬化特征，并且LDL2亚组分在动脉粥样硬化过程中具有双重作用，具体取决于个体的表型（动脉粥样硬化/非动脉粥样硬化）。与NAG相比，AG中的男性的LDL1水平明显较低，而LDL2和LDL3-7亚组分水平较高。在NAG中，LDL2与sHDL子分数呈正相关，而在AG中，HDL子分数大。结论我们的研究结果表明，与女性相比，男性具有更多的动脉粥样硬化特征，并且LDL2亚组分在动脉粥样硬化过程中具有双重作用，具体取决于个体的表型（动脉粥样硬化/非动脉粥样硬化）。