Pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), play a pivotal role in the initiation of innate immune responses. Certain PRRs are also expressed by CD4+ and CD8+ T cells, where they function to provide co-stimulatory signals for their activation and differentiation. Recently, stimulator of interferon genes (STING) was found to be highly expressed in CD4+ and CD8+ T cells and to modulate T cell function. STING signaling inhibits cell growth and stimulates type I interferon (IFN-I) responses in T cells through reciprocal regulation between T cell receptor (TCR) and STING signals. Here, we propose a model whereby innate signals by TLRs and STING regulate TCR signals and T cell functions.

中文翻译：

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T细胞通过先天信号共同刺激和功能调节。

模式识别受体（PRR），例如Toll样受体（TLR），NOD样受体（NLR）和RIG-1样受体（RLR），在先天免疫应答的启动中起关键作用。某些PRR也由CD4 +和CD8 + T细胞表达，在这些细胞中，它们的功能是为它们的活化和分化提供共刺激信号。最近，发现干扰素基因的刺激物（STING）在CD4 +和CD8 + T细胞中高表达并调节T细胞功能。STING信号传导通过T细胞受体（TCR）和STING信号之间的相互调节，抑制细胞生长并刺激T细胞中的I型干扰素（IFN-I）反应。在这里，我们提出一个模型，借以TLR和STING的先天信号调节TCR信号和T细胞功能。