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Frozen IVF Cycles to Circumvent the Hormonal Storm on Endometrium.
Trends in Endocrinology & Metabolism ( IF 9.777 ) Pub Date : 2020-02-05 , DOI: 10.1016/j.tem.2020.01.009
Paola Viganò,Alessandra Alteri,Andrea Busnelli,Valeria Stella Vanni,Edgardo Somigliana

Controlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical trials. There is growing agreement that in patients hyper-responding to COH and in those undergoing transfer at the blastocyst stage, deferring the transfer in a subsequent frozen cycle could increase pregnancy outcomes. For blastocysts, implantation after a fresh transfer may be limited as the implantation window is already closed while, in hyper-responders to COH, the anticipation magnitude could be more marked thus hampering implantation also for cleavage-stage embryos. Research should focus in depth on pregnancy outcomes and on the most suitable modality to prepare the endometrium for frozen transfers.
更新日期:2020-02-06

 

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