DNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.

中文翻译：

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细胞内的DEL。

DNA编码文库（DEL）包含大量小分子，每个小分子都与编码DNA偶联。Krusemark及其同事最近描述了一种将DEL引入活细胞并回收与细胞内靶标结合的结合物的方法。这项原理验证研究表明，针对其天然环境中的蛋白质靶标筛选DEL可能是可行的。