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Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium-glucose cotransporter 2 inhibitor administration.
Journal of Diabetes Investigation ( IF 3.2 ) Pub Date : 2020-02-27 , DOI: 10.1111/jdi.13228
Taro Hirai 1 , Munehiro Kitada 1 , Yoshihiro Hayashi 1 , Itaru Monno 1 , Yuta Takagaki 1 , Keiji Shimada 1 , Yoshio Ogura 1 , Mizue Fujii 1 , Kazunori Konishi 1 , Atsushi Nakagawa 1 , Daisuke Koya 1
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A 58‐year‐old women who was diagnosed with type 2 diabetes 20 years earlier had been treated with antidiabetic medicines since she was aged 40 years. After sodium–glucose cotransporter 2 inhibitors administration, her bodyweight rapidly decreased from 40 to 30 kg over a period of 3 weeks. She had abdominal symptoms, including nausea, especially after a meal. On admission, physical examinations and laboratory data showed euglycemic ketoacidosis, dehydration and low insulin secretion levels. Additionally, abdominal contrast computed tomography showed the finding of superior mesenteric artery syndrome. This case urges caution, including rapid excessive bodyweight loss and euglycemic ketoacidosis, on the use of sodium–glucose cotransporter 2 for lean diabetes patients.

中文翻译:

一例瘦型 2 型糖尿病患者发生肠系膜上动脉综合征的病例报告,该综合征与钠-葡萄糖协同转运蛋白 2 抑制剂给药后体重迅速减轻有关。

一名 58 岁的女性在 20 年前被诊断出患有 2 型糖尿病,她从 40 岁开始就接受抗糖尿病药物治疗。服用钠-葡萄糖协同转运蛋白 2 抑制剂后,她的体重在 3 周内迅速从 40 公斤减至 30 公斤。她有腹部症状,包括恶心,尤其是饭后。入院时,体格检查和实验室数据显示正常血糖酮症酸中毒、脱水和低胰岛素分泌水平。此外,腹部对比计算机断层扫描显示肠系膜上动脉综合征的发现。该病例敦促对瘦型糖尿病患者使用钠 - 葡萄糖协同转运蛋白 2 时要谨慎,包括快速过度体重减轻和正常血糖酮症酸中毒。
更新日期:2020-02-27
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