Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B-labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR-loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR-loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK.

中文翻译：

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负载柔红霉素的可生物降解周期性介孔有机二氧化硅（BPMO）：一种有前景的纳米颗粒抗癌药物。


鉴于可生物降解的特性有利于临床转化，可生物降解的周期性介孔有机二氧化硅（BPMO）纳米颗粒已成为一种有前途的药物输送纳米载体。在本文中，我们报道了负载柔红霉素 (DNR) 的 BPMO 的合成和表征。 DNR 被负载到含有四硫键的罗丹明 B 标记的 BPMO 上。使用肿瘤球体和鸡蛋肿瘤模型来表征生物环境中的活性。在第一个实验中，我们检查了由卵巢癌细胞制备的肿瘤球体对 BPMO 的摄取情况。 BPMO 被有效地吸收到肿瘤球体中并抑制其生长。在鸡蛋肿瘤模型中，静脉注射负载 DNR 的 BPMO 可消除卵巢肿瘤。对肺等器官没有不利影响似乎是由于 BPMO 在肿瘤中的良好积累。因此，与目前用于癌症治疗的游离 DNR 相比，负载 DNR 的 BPMO 代表了一种有前途的纳米药物。好的。