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Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration.
International Journal of Oral Science ( IF 10.8 ) Pub Date : 2020-02-06 , DOI: 10.1038/s41368-020-0073-y
Lisha Zhu 1 , Dan Luo 2 , Yan Liu 1
Affiliation  

Natural bone is a mineralized biological material, which serves a supportive and protective framework for the body, stores minerals for metabolism, and produces blood cells nourishing the body. Normally, bone has an innate capacity to heal from damage. However, massive bone defects due to traumatic injury, tumor resection, or congenital diseases pose a great challenge to reconstructive surgery. Scaffold-based tissue engineering (TE) is a promising strategy for bone regenerative medicine, because biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Additionally, the defined structure of biomaterial scaffolds, as a kind of mechanical cue, can influence cell behaviors, modulate local microenvironment and control key features at the molecular and cellular levels. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE for the reconstruction of bone defects. For this reason, it is necessary for us to have in-depth knowledge of the development of novel nano/micro-based biomaterial scaffolds. Thus, we herein review the hierarchical structure of bone, and the potential application of nano/micro technologies to guide the design of novel biomaterial structures for bone repair and regeneration.

中文翻译:


生物材料支架的纳米/微米结构对骨再生的影响。



天然骨骼是一种矿化生物材料,为身体提供支持和保护框架,储存新陈代谢所需的矿物质,并产生滋养身体的血细胞。通常,骨骼具有从损伤中愈合的天生能力。然而,由于创伤、肿瘤切除或先天性疾病导致的大量骨缺损给重建手术带来了巨大的挑战。基于支架的组织工程(TE)是骨再生医学的一种有前途的策略,因为生物材料支架表现出先进的机械性能和良好的降解特性,以及控制生长和分化因子的释放或将它们固定在材料表面上的可行性。此外,生物材料支架的明确结构作为一种机械线索,可以影响细胞行为,调节局部微环境并控制分子和细胞水平的关键特征。最近,纳米/微米辅助再生医学成为TE在骨缺损重建方面的一个有前景的应用。因此,我们有必要深入了解新型纳米/微米生物材料支架的开发。因此,我们在此回顾了骨的分层结构,以及纳米/微米技术的潜在应用,以指导用于骨修复和再生的新型生物材料结构的设计。
更新日期:2020-02-06
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