Increased arterial velocity pulse index is an independent factor related to skeletal muscle mass reduction and tissue damage in patients with cardiovascular disease,Hypertension Research

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Increased arterial velocity pulse index is an independent factor related to skeletal muscle mass reduction and tissue damage in patients with cardiovascular disease
Hypertension Research ( IF 4.3 ) Pub Date : 2020-02-05 , DOI: 10.1038/s41440-020-0404-6
Haruhito Harada ₁ , Hisao Ikeda ₂ , Yasuhiro Nishiyama ₁ , Hiroshi Niiyama ₁ , Atsushi Katoh ₁ , Hisashi Kai ₁

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Reduced skeletal muscle mass is the most important component of sarcopenia. Aging and chronic diseases, including chronic heart failure, are the causes of reduced skeletal muscle mass. However, little is known about the mechanism of skeletal muscle mass reduction in patients with cardiovascular disease (CVD). The purpose of this study was to assess the associations among skeletal muscle mass reduction, endothelial function, and other markers of advanced vascular damage in CVD patients. This was a retrospective cross-sectional analysis that included 310 inpatients with CVD in our hospital. Flow-mediated vasodilation (FMD) was performed to assess early vascular damage, i.e., endothelial dysfunction. The arterial velocity pulse index (AVI) and arterial pressure volume index (API) were assessed to reveal signs of advanced vascular damage, such as arterial stiffening and increased peripheral resistance. The bioelectrical phase angle (PA), as a marker of tissue damage, and the skeletal muscle index (SMI) were measured. Correlation analyses were performed among these parameters. Sarcopenia was diagnosed in 25.5% of patients according to the Asian Working Group for Sarcopenia criteria. Greater progression of arterial stiffness, shown by a higher AVI, and more severe tissue damage, shown by a narrower PA, were found in individuals with sarcopenia. Stepwise multivariate regression analysis showed that sex, age, PA, hypertension, and AVI were factors independently correlated with SMI. In conclusion, advanced vascular damage, such as increased arterial stiffness and peripheral resistance, might play an important role in the reduction in skeletal muscle mass, possibly through damage to skeletal muscle tissue in CVD patients.

中文翻译：

动脉速度脉搏指数增加是与心血管疾病患者骨骼肌质量减少和组织损伤相关的独立因素

骨骼肌质量减少是肌肉减少症最重要的组成部分。衰老和慢性疾病，包括慢性心力衰竭，是骨骼肌质量减少的原因。然而，关于心血管疾病 (CVD) 患者骨骼肌质量减少的机制知之甚少。本研究的目的是评估 CVD 患者骨骼肌质量减少、内皮功能和其他晚期血管损伤标志物之间的关联。这是一项回顾性横断面分析，包括我院 310 名 CVD 住院患者。进行血流介导的血管舒张 (FMD) 以评估早期血管损伤，即内皮功能障碍。评估动脉速度脉搏指数 (AVI) 和动脉压容积指数 (API) 以揭示晚期血管损伤的迹象，例如动脉硬化和外周阻力增加。测量了作为组织损伤标志物的生物电相位角 (PA) 和骨骼肌指数 (SMI)。在这些参数之间进行相关分析。根据亚洲肌肉减少症工作组标准，25.5% 的患者被诊断为肌肉减少症。在患有肌肉减少症的个体中发现动脉僵硬度的进展更大，表现为更高的 AVI 和更严重的组织损伤，表现为更窄的 PA。逐步多元回归分析显示，性别、年龄、体力活动、高血压和AVI是与SMI独立相关的因素。总之，晚期血管损伤，如动脉僵硬和外周阻力增加，可能在骨骼肌质量的减少中起重要作用，

更新日期：2020-02-05

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