Functional alterations in the subregions of the anterior cingulate cortex (ACC) have been observed in patients with major depressive disorder (MDD). Studies have shown that higher depressive symptoms are associated with altered functional connectivity (FC) in different ACC sub-regions. Suicide is highly prevalent in patients with MDD; however, it is unclear whether suicidal behavior is associated with the FC alterations in the subregions of the ACC in these indibiduals. Seventy-six patients with MDD (41 with and 35 without a history of suicidal behavior) underwent functional magnetic resonance imaging (fMRI) and were assessed using the Hamilton Rating Scale for Depression (HAMD), the Scale for Suicide Ideation (SSI), and the Columbia Scale for Rating of Suicide Severity. We investigated the FC between the ACC subregions and other brain regions in young MDD patients with and without a history of suicidal behavior. The FC in the subregions of the ACC-superior frontal gyrus differed significantly between the two groups. Additionally, the anterior sgACC-right caudate FC and the pgACC-left insula FC were found to be abnormal in the suicidal MDD group. Interestingly, the suicidal ideation score positively correlated with decreased FC in the pgACC-superior frontal gyrus in both groups, but it negatively correlated with increased FC in the anterior sgACC-superior frontal gyrus in the non-suicidal MDD group. Our findings indicate that altered connections of subregions in the ACC may be involved in the neurological mechanisms underlying suicide in young adults with MDD.

中文翻译：

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年轻人前扣带回皮层的静息状态功能连通性使有抑郁和无自杀行为的抑郁患者受益。

在患有严重抑郁症（MDD）的患者中观察到前扣带回皮层（ACC）子区域的功能改变。研究表明，在不同的ACC子区域中，较高的抑郁症状与功能连接性（FC）的改变有关。自杀在MDD患者中非常普遍。然而，目前尚不清楚这些个体的自杀行为是否与ACC子区域的FC改变有关。76例MDD患者（41例和35例没有自杀行为）接受了功能磁共振成像（fMRI），并使用汉密尔顿抑郁量表（HAMD），自杀意念量表（SSI）和哥伦比亚自杀严重程度量表。我们调查了有和没有自杀行为史的年轻MDD患者的ACC子区域与其他大脑区域之间的FC。两组之间，ACC上额回的子区域中的FC显着不同。另外，在自杀MDD组中，前sgACC-右尾状核FC和pgACC-左绝缘核FC异常。有趣的是，自杀意念得分与pgACC上额额回中的FC降低呈正相关，但与非自杀MDD组中sgACC额上回中的FC呈负相关。我们的研究结果表明，ACC子区域的连接改变可能与MDD青年自杀的神经机制有关。