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The effects of concurrent training order on body composition and serum concentrations of follistatin, myostatin and GDF11 in sarcopenic elderly men.
Experimental Gerontology ( IF 3.3 ) Pub Date : 2020-02-05 , DOI: 10.1016/j.exger.2020.110869
Reza Bagheri 1 , Babak Hooshmand Moghadam 2 , David D Church 3 , Grant M Tinsley 4 , Mozhgan Eskandari 5 , Bizhan Hooshmand Moghadam 5 , Mohammad S Motevalli 2 , Julien S Baker 6 , Robert A Robergs 7 , Alexei Wong 8
Affiliation  

BACKGROUND Due to the important role of follistatin (FLST), myostatin (MSTN) and growth differentiation factor 11 (GDF11) in muscle mass regulation; alterations in the FLST to MSTN ratio (F:M) may result in muscle mass changes in response to different concurrent training (CT) order. This study investigated the influence of 8 weeks of CT order on body composition and serum concentrations of FLST, MSTN, their ratio (F:M) and GDF11 in sarcopenic elderly men. METHODS Thirty sarcopenic elderly men (age = 64.3 ± 3.5 years) were randomly assigned into one of three groups, endurance followed by resistance training (E + R; n = 10), resistance followed by endurance training (R + E; n = 10) or control (C; n = 10). Serum concentrations of muscle regulatory markers, body composition, maximum rate of oxygen consumption (VO2max), and upper and lower body strength were evaluated at baseline and after 8 weeks. The training protocol consisted of three training sessions per week for eight weeks. RESULTS There were significant group-by-time interactions (P < 0.05) for FLST, MSTN, GDF11 and F:M ratio. FLST (E + R = 187 pg/mL and R + E = 292 pg/mL) and F:M ratio (E + R = 0.20 and R + E = 0.27) significantly increased (P < 0.05) while MSTN (E + R = -308 pg/mL and R + E = -294 pg/mL) and GDF11 (E + R = -12 pg/mL and R + E = -10 pg/mL) significantly decreased (P < 0.05) following eight weeks in the E + R and R + E compared to no changes in the C group. In addition, there were significant group x time interactions (P < 0.01) for weight, BMI, body fat percentage (BFP), skeletal muscle mass (SMM), VO2max, upper body strength, and lower body strength. BFP (E + R = -1.5% and R + E = -2%) significantly decreased (P < 0.01) while weight (E + R = 2.4 kg and R + E = 1.1 kg), BMI (E + R = 0.8 kg/m2 and R + E = 0.3 kg/m2), SMM (E + R = 0.7 kg and R + E = 0.5 kg), VO2max (E + R = 2.0 mL/kg/min and R + E = 1.8 mL/kg/min), upper body strength (E + R = 6.9 kg and R + E = 2.3 kg), and lower body strength (E + R = 9.8 kg and R + E = 4.4 kg) significantly increased (P < 0.01) in the E + R and R + E compared to no changes in the C group. CONCLUSIONS CT increases the F:M ratio and FLST as well as reducing MSTN and GDF11 in sarcopenic elderly men. Additionally, CT improved weight, body composition, muscle mass, function, and aerobic fitness. Notably, these results after CT were achieved irrespective of endurance and resistance exercise order in this population.

中文翻译:

并行训练顺序对少肌症老年男性身体成分和血清卵泡抑素、肌肉生长抑制素和 GDF11 浓度的影响。

背景由于卵泡抑素(FLST)、肌肉生长抑制素(MSTN)和生长分化因子11(GDF11)在肌肉质量调节中的重要作用;FLST 与 MSTN 比率 (F:M) 的变化可能会导致肌肉质量因不同的同时训练 (CT) 顺序而发生变化。本研究调查了 8 周 CT 顺序对肌肉减少的老年男性的身体成分和 FLST、MSTN 的血清浓度、它们的比率 (F:M) 和 GDF11 的影响。方法 30 名肌肉减少的老年男性(年龄 = 64.3 ± 3.5 岁)被随机分配到三组中的一组,耐力训练后进行阻力训练(E + R;n = 10),阻力训练后进行耐力训练(R + E;n = 10) ) 或对照 (C; n = 10)。肌肉调节标志物的血清浓度、身体成分、最大耗氧量 (VO2max)、在基线和 8 周后评估上下肢力量。培训方案包括每周三期培训课程,为期八周。结果 FLST、MSTN、GDF11 和 F:M 比率存在显着的组间交互作用(P < 0.05)。FLST (E + R = 187 pg/mL 和 R + E = 292 pg/mL) 和 F:M 比率 (E + R = 0.20 和 R + E = 0.27) 显着增加 (P < 0.05) 而 MSTN (E + R = -308 pg/mL 和 R + E = -294 pg/mL) 和 GDF11 (E + R = -12 pg/mL 和 R + E = -10 pg/mL) 在八次之后显着降低 (P < 0.05)在E+R和R+E周相比,C组没有变化。此外,体重、BMI、体脂百分比 (BFP)、骨骼肌质量 (SMM)、VO2max、上肢力量和下肢力量之间存在显着的组 x 时间交互作用 (P < 0.01)。BFP (E + R = -1。5% 和 R + E = -2%) 显着下降 (P < 0.01) 而体重 (E + R = 2.4 kg 和 R + E = 1.1 kg)、BMI (E + R = 0.8 kg/m2 和 R + E = 0.3 kg/m2), SMM (E + R = 0.7 kg and R + E = 0.5 kg), VO2max (E + R = 2.0 mL/kg/min and R + E = 1.8 mL/kg/min), 上在 E + R 和R+E相比C组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。01) 而体重 (E + R = 2.4 kg 和 R + E = 1.1 kg)、BMI (E + R = 0.8 kg/m2 和 R + E = 0.3 kg/m2)、SMM (E + R = 0.7 kg 和R + E = 0.5 kg),最大摄氧量(E + R = 2.0 mL/kg/min 和 R + E = 1.8 mL/kg/min),上身力量(E + R = 6.9 kg 和 R + E = 2.3 kg ),下肢力量 (E + R = 9.8 kg 和 R + E = 4.4 kg) 在 E + R 和 R + E 中显着增加 (P < 0.01),而 C 组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。01) 而体重 (E + R = 2.4 kg 和 R + E = 1.1 kg)、BMI (E + R = 0.8 kg/m2 和 R + E = 0.3 kg/m2)、SMM (E + R = 0.7 kg 和R + E = 0.5 kg),最大摄氧量(E + R = 2.0 mL/kg/min 和 R + E = 1.8 mL/kg/min),上身力量(E + R = 6.9 kg 和 R + E = 2.3 kg ),下肢力量 (E + R = 9.8 kg 和 R + E = 4.4 kg) 在 E + R 和 R + E 中显着增加 (P < 0.01),而 C 组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。7 kg 和 R + E = 0.5 kg),最大摄氧量(E + R = 2.0 mL/kg/min 和 R + E = 1.8 mL/kg/min),上身力量(E + R = 6.9 kg 和 R + E = 2.3 kg),下肢力量 (E + R = 9.8 kg 和 R + E = 4.4 kg) 在 E + R 和 R + E 中显着增加 (P < 0.01),而 C 组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。7 kg 和 R + E = 0.5 kg),最大摄氧量(E + R = 2.0 mL/kg/min 和 R + E = 1.8 mL/kg/min),上身力量(E + R = 6.9 kg 和 R + E = 2.3 kg),下肢力量 (E + R = 9.8 kg 和 R + E = 4.4 kg) 在 E + R 和 R + E 中显着增加 (P < 0.01),而 C 组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。01)在E+R和R+E相比,C组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。01)在E+R和R+E相比,C组没有变化。结论 CT 增加了肌少症老年男性的 F:M 比和 FLST,并降低了 MSTN 和 GDF11。此外,CT 改善了体重、身体成分、肌肉质量、功能和有氧健康。值得注意的是,无论该人群的耐力和阻力运动顺序如何,CT 后的这些结果都是如此。
更新日期:2020-02-06
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