Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact and migrate using the two fundamentally different types of force, remote and contact forces, and show how cells form a large-scale structure. We demonstrate that the simple model reproduces experimental observations, suggesting that the remote and contact forces considered in this work play a major role in large-scale structure formation of HeLa cells. This article provides important evidence that cancer cells form a large-scale structure and develops an understanding into the poorly understood mechanisms of their structure formation.

中文翻译：

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远程和接触力在上皮细胞结构形成中的作用

癌细胞为它们的生长共同形成了一个大规模的结构。在这篇文章中，我们报告了 HeLa 细胞，上皮样人类宫颈癌细胞，在基质胶上积极迁移并以细胞密度依赖性方式形成大规模结构。为了解释实验结果，我们开发了一个简单的模型，其中细胞使用两种根本不同类型的力（远程力和接触力）相互作用和迁移，并展示了细胞如何形成大规模结构。我们证明了简单模型再现了实验观察结果，表明这项工作中考虑的远程和接触力在 HeLa 细胞的大规模结构形成中起着重要作用。