Noble thermosensitive nanoparticles, based on a PNIPAAm-co-AA core and a chitosan shell structure, were designed and synthesized for the controlled release of the loaded drug. PNIPAAm nanoparticles containing a carboxylic group on their surface were synthesized using emulsion polymerization. The carboxylic groups were conjugated with the amino group of a low molecular weight, water soluble chitosan. The particle size of the synthesized nanoparticles was decreased from 380 to 25 nm as the temperature of the dispersed medium was increased. Chitosan-conjugated nanoparticles with 2∼5 wt% MBA, a crosslinking monomer, induced a stable aqueous dispersion at a concentration of 1 mg/1 mL. The chitosan-conjugated nanoparticles showed thermosensitive behaviors such as LCST and size shrinkage that were affected by the PNIPAAm core and induced some particle aggregation around LCST, which was not shown in the NIPAAm-co-AA nanoparticles. These chitosan-conjugated nanoparticles are also expected to be more biocompatible than the PNIPAAm core itself through the chitosan shell structures.

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基于PNIPAAm核和壳聚糖壳结构的热敏纳米粒子的合成与表征

贵金属热敏纳米粒子，基于PNIPAAm- co设计并合成了-AA核心和壳聚糖壳结构，用于控制释放的负载药物。使用乳液聚合合成了表面上含有羧基的PNIPAAm纳米粒子。羧基与低分子量水溶性壳聚糖的氨基缀合。随着分散介质温度的升高，合成纳米颗粒的粒径从380纳米降低到25纳米。具有2〜5 wt％MBA（一种交联单体）的壳聚糖共轭纳米颗粒可诱导稳定的水分散液，浓度为1 mg / 1 mL。壳聚糖缀合的纳米颗粒表现出受PNIPAAm核心影响的热敏行为，例如LCST和尺寸收缩，并引起LCST周围的一些颗粒聚集，这在NIPAAm-中没有显示。co- AA纳米粒子。通过壳聚糖壳结构，这些与壳聚糖结合的纳米颗粒还有望比PNIPAAm核心本身更具生物相容性。