Whole genome sequencing (WGS) has been proposed as a tool for the diagnosis of drug resistance in tuberculosis (TB); however, there have been few studies on its effectiveness in countries with significantly high drug resistance rates. This study therefore aimed to evaluate the effectiveness of WGS to identify mutations related to drug resistance in TB isolates from an endemic region of Mexico. The results showed that, of 35 multidrug-resistant isolates analyzed, the values of congruence found between the phenotypic drug susceptibility testing and polymorphisms were 94% for isoniazid, 97% for rifampicin, 90% for ethambutol, and 82% for pyrazinamide. It was also possible to identify eight isolates as potential pre-extensive drug resistant (XDR) and one as XDR. Twenty nine isolates were classified within L4 and two transmission clusters were identified.

中文翻译：

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通过全基因组测序对与耐多药结核病相关的多态性进行表征：来自墨西哥的初步报告。

已经提出了全基因组测序（WGS）作为诊断结核病（TB）耐药性的工具。但是，在耐药率很高的国家中，关于其有效性的研究很少。因此，本研究旨在评估WGS鉴定在墨西哥流行地区的结核病分离株中与耐药性相关的突变的有效性。结果表明，在分析的35种耐多药菌株中，表型药物敏感性测试与多态性之间的一致性值为异烟肼94％，利福平97％，乙胺丁醇90％，吡嗪酰胺82％。还可能将八种分离株鉴定为潜在的广泛耐药性（XDR），另一种鉴定为XDR。