Celiac Disease (CD) is an immune-mediated enteropathy, generally of the proximal intestine, that occurs in genetically susceptible individuals triggered by the ingestion of gluten. The incidence and frequency of CD are increasing, and it is predicted that CD affects approximately 1% of the people worldwide. The common clinical manifestations of CD are divided in two sections, including classic and non-classic symptoms that can be created in childhood and adulthood. The relationship between pathogenic and non-pathogenic bacteria with CD is complex and multidirectional. In previous published studies, results demonstrated the triggering impact of bacteria, viruses, and parasites on initiation and development of Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). Different studies revealed the inducing effect of pathogenic and non-pathogenic bacteria on CD. However, increasing evidence proposes that some of these microorganisms can also play several positive roles in CD process. Although information of the pathogenesis of the CD is quickly expanding, the possible role of bacteria needs further examination. In conclusion, with respect to the possible correlation between different bacteria in CD, the current review-based study aims to discuss the possible relationship between CD and pathogenic and non-pathogenic bacteria and to show various and significant aspects of mechanisms involved in the CD process.

乳糜泻（CD）是一种免疫介导的肠病，通常是近端肠道的肠病，发生于因摄入麸质而引起遗传易感的个体中。CD的发生率和频率在增加，据预测CD会影响全世界约1％的人。CD的常见临床表现分为两个部分，包括儿童期和成年期可能产生的经典和非经典症状。CD致病菌和非致病菌之间的关系是复杂的，多方向的。在先前发表的研究中，结果证明了细菌，病毒和寄生虫对炎性肠病（IBD）和肠易激综合症（IBS）的发生和发展的触发作用。不同的研究揭示了致病性和非致病性细菌对CD的诱导作用。然而，越来越多的证据表明，这些微生物中的某些也可以在CD过程中发挥若干积极作用。尽管有关CD发病机理的信息正在迅速扩大，但细菌的可能作用还需要进一步研究。总之，关于CD中不同细菌之间的可能相关性，当前基于综述的研究旨在探讨CD与致病性和非致病性细菌之间的可能关系，并展示CD过程中涉及的各种重要机制。 。尽管有关CD发病机理的信息正在迅速扩大，但细菌的可能作用还需要进一步研究。总之，关于CD中不同细菌之间的可能相关性，当前基于综述的研究旨在探讨CD与致病性和非致病性细菌之间的可能关系，并展示CD过程中涉及的各种重要机制。 。尽管CD发病机理的信息正在迅速扩大，但细菌的可能作用还需要进一步研究。总之，关于CD中不同细菌之间的可能相关性，当前基于综述的研究旨在探讨CD与致病性和非致病性细菌之间的可能关系，并展示CD过程中涉及的各种重要机制。 。