Collagen is a structural protein that is widely present in vertebrates, being usually distributed in tissues in the form of fibers. In living organisms, fibers are organized in different orientations in various tissues. As the structural base in connective tissue and load-bearing tissue, the orientation of collagen fibers plays an extremely important role in the mechanical properties and physiological and biochemical functions. The study on mechanics role in formation of oriented collagen fibers enables us to understand how discrete cells use limited molecular materials to create tissues with different structures, thereby promoting our understanding of the mechanism of tissue formation from scratch, from invisible to tangible. However, the current understanding of the mechanism of fiber orientation is still insufficient. In addition, existing fabrication methods of oriented fibers are varied and involve interdisciplinary study, and the achievements of each experiment are favorable to the construction and improvement of the fiber orientation theory. To this end, this review focuses on the preparation methods of oriented fibers and proposes a model explaining the formation process of oriented fibers in tendons based on the existing fiber theory.

中文翻译：

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定向胶原纤维形成中的机械作用。

胶原蛋白是一种广泛存在于脊椎动物中的结构蛋白，通常以纤维形式分布在组织中。在活生物体中，纤维在各种组织中以不同的方向组织。作为结缔组织和承重组织的结构基础，胶原纤维的取向在机械性能和生理生化功能中起着极其重要的作用。对定向胶原纤维形成过程中的力学作用的研究使我们能够理解离散细胞如何使用有限的分子材料来创建具有不同结构的组织，从而增进我们对从无到有从无到有的从头开始的组织形成机理的理解。但是，目前对纤维取向机理的理解仍然不足。此外，现有的定向纤维的制备方法是多种多样的，涉及到交叉学科，每个实验的成果有利于纤维定向理论的建立和完善。为此，本综述着重介绍了定向纤维的制备方法，并基于现有的纤维理论，提出了一种解释腱中定向纤维形成过程的模型。