Background: Conceptually, a tissue engineered heart valve would be especially appealing in the pediatric setting since small size and somatic growth constraints would be alleviated. In this study, we utilized porcine small intestinal submucosa (PSIS) for valve replacement. Of note, we evaluated the material responses of PSIS and subsequently its acute function and somatic growth potential in the mitral position.

中文翻译：

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猪小肠粘膜下二尖瓣材料反应支持急性体细胞生长。

背景：从概念上讲，组织工程化的心脏瓣膜在儿科环境中将特别有吸引力，因为这将减轻小尺寸和体细胞生长的限制。在这项研究中，我们利用猪小肠粘膜下层（PSIS）进行瓣膜置换。值得注意的是，我们评估了PSIS的物质反应，随后评估了其在二尖瓣位置的急性功能和体细胞生长潜力。