The reaction of spillover hydrogen (SH) with cyclopropylglycine (cPG) in high-temperature solid-state catalytic hydrogen isotope exchange (HTCIE) has been studied experimentally and using density functional theory (DFT). NMR spectroscopy and mass spectrometry have shown a high regioselectivity and stereoselectivity for the reaction of spillover hydrogen with cPG fragments. The Gly fragment has been shown to be the most reactive in HTCIE, for which high stereoselectivity of substitution of hydrogen by deuterium has been demonstrated.

中文翻译：

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环丙基甘氨酸中氢与氘的固态催化同位素交换

溢出氢 (SH) 与环丙基甘氨酸 (cPG) 在高温固态催化氢同位素交换 (HTCIE) 中的反应已使用密度泛函理论 (DFT) 进行了实验研究。核磁共振波谱和质谱显示了溢出氢与 cPG 片段反应的高区域选择性和立体选择性。Gly 片段已被证明在 HTCIE 中是最具反应性的，为此已经证明了氢被氘取代的高立体选择性。