5ʹUTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls—Preliminary evidence,SYNAPSE

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5ʹUTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls—Preliminary evidence
SYNAPSE ( IF 1.6 ) Pub Date : 2020-01-07 , DOI: 10.1002/syn.22147
Katharina Ledermann _{1,

2} , Gregor Hasler ₁ , Josef Jenewein _{2,

3} , Haiko Sprott ₄ , Ulrich Schnyder ₅ , Chantal Martin-Soelch ₁

Affiliation

Extensive literature has investigated the role of serotonin (5‐HT) in the control of the central dopamine (DA) systems, and their dysfunction in the pathological conditions. 5‐HT stimulates the local DA release in striatal regions via activation of various receptors including serotonin receptor‐3 (5‐HT3). Several studies have related polymorphisms (SNPs) in the serotonin receptor‐3 (HTR3) genes to be associated with the pain modulation and endogenous pain suppression. A few studies suggested a functional role of 5ʹUTR SNP in the serotonergic receptor HTR3A gene (rs1062613) in the development of the chronic pain and Fibromyalgia syndrome (FMS) in particular. Here, we investigated the effect of a 5ʹUTR SNP in the serotonergic receptor HTR3A gene (rs1062613) on striatal dopamine D2/D3 receptor (DRD2) availability and reward‐associated DA release in response to unpredictable monetary rewards in 23 women with FMS and 17 age‐matched healthy female controls. Furthermore, we aimed to examine if SNP rs1062613 is associated with thermal pain and pain tolerance thresholds.

中文翻译：

5-羟色胺能受体 HTR3A 基因中的 5ʹUTR 多态性与纤维肌痛患者和健康对照组右侧壳核中纹状体多巴胺 D2/D3 受体的可用性不同——初步证据

大量文献研究了血清素 (5-HT) 在控制中枢多巴胺 (DA) 系统中的作用及其在病理条件下的功能障碍。5-HT 通过激活包括 5-羟色胺受体-3 (5-HT3) 在内的各种受体来刺激纹状体区域的局部 DA 释放。几项研究表明，血清素受体 3 (HTR3) 基因的多态性 (SNP) 与疼痛调节和内源性疼痛抑制有关。一些研究表明，血清素受体HTR3A基因 (rs1062613) 中的5ʹUTR SNP 在慢性疼痛和纤维肌痛综合征 (FMS) 的发展中具有功能作用。在这里，我们研究了 5ʹUTR SNP 对血清素受体HTR3A 的影响基因 (rs1062613) 对纹状体多巴胺 D2/D3 受体 (DRD2) 可用性和奖励相关 DA 释放的影响，以响应 23 名患有 FMS 的女性和 17 名年龄匹配的健康女性对照组的不可预测的金钱奖励。此外，我们旨在检查 SNP rs1062613 是否与热痛和疼痛耐受阈值相关。

更新日期：2020-03-27

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