This study reports the preparation and characterization of nanohydrogels by using sodium alginate as a model material. Alginate nanohydrogels (ANH) were prepared by emulsification-diffusion method in a w/o system with 1,2-diacyl-sn-glycero-3-phosphocholin as the lipophilic surfactant. The effects of the alginate to surfactant ratio and the remaining water contents on the mean particle size and swellability of ANHs were investigated in terms of the concentration, agitation speed, and agitation time. The feasibility of using nanohydrogels and their controllability were proved by the water the absorbency of ANHs during a 7-day evaluation by dynamic light scattering. In this work, the mean particle sizes of ANHs could be controlled from 49.2 nm (measured in ethanol phase) to 1.9 ώm (measured in water phase, after 7 days of water absorption).

中文翻译：

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乳化-扩散法制备的藻酸盐纳米水凝胶

这项研究报告了以藻酸钠为模型材料制备和表征纳米水凝胶。以1,2-二酰基-sn-甘油-3-磷酸胆碱为亲脂性表面活性剂，通过乳化-扩散法在w / o系统中制备藻酸盐纳米水凝胶。从浓度，搅拌速度和搅拌时间的角度研究了藻酸盐与表面活性剂之比和剩余水含量对ANHs平均粒径和溶胀性的影响。通过水在7天的动态光散射评估中，ANHs的吸水率证明了使用纳米水凝胶的可行性及其可控性。在这项工作中，可以将ANHs的平均粒径控制在49.2 nm（在乙醇相中测量）到1.9μm（在吸水7天后在水相中测量）。