Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.

中文翻译：

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环丙沙星与吡嗪酸和对氨基苯甲酸的新共晶体的机械化学合成，表征和热研究

在液体辅助研磨（LAG /乙醇）和纯磨的条件下，通过机械化学方法获得了环丙沙星与吡嗪酸和对氨基苯甲酸的化学计量比为1：1的新型共晶体。它们的特征在于粉末X射线衍射仪，红外光谱仪，同时热重分析仪，差热分析仪，差示扫描量热仪（DSC）和DSC显微系统。结果证实了共晶体的成功合成，并表明了负责形成新的超分子合成子的官能团。此外，通过热分析，可以评估热稳定性，组成，加热过程中的结晶过程，多晶型转变并构建二元相图。