Background

Endometriosis is one of the most common gynecological diseases of reproductive age, with a prevalence of 5–10% and grave consequences for quality of life and fertility. Vitamin D (vit D), a classic regulator of plasma calcium concentration and skeleton mineralization, is also an effective modulator of the immune system. Several studies suggest that immunologic properties attributed to vit D along with vit D receptor (VDR) expression in reproductive tissues may be involved in the pathogenesis of endometriosis.

Objective

To systematically review the literature for the association between components of vit D metabolism and endometriosis.

Materials and methods

A systematic review of the literature published in the Medline and Cochrane Central databases was conducted for original research articles on humans, published in any language.

Results

Twenty-one studies were included in the systematic review. Among them, 12 examined the relationship of endometriosis with vit D metabolites, eight with vit D–binding protein (VDBP), three with VDR polymorphisms, and two with vit D regulatory enzymes. There are discrepancies between the outcomes of the available literature publications.

Conclusions

This is a systematic attempt to collect, evaluate, and present the known data on the association between vit D and endometriosis. Given the heterogeneity and the diversity of the present studies, more research is required to elucidate the association between vit D and endometriosis.

中文翻译：

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维生素D与子宫内膜异位之间的关联：系统评价。

背景

子宫内膜异位症是生殖年龄最常见的妇科疾病之一，患病率为5-10％，对生活质量和生育能力造成严重影响。维生素D（维生素D）是血浆钙浓度和骨骼矿物质的经典调节剂，也是免疫系统的有效调节剂。几项研究表明，在生殖组织中归因于vit D以及vit D受体（VDR）表达的免疫学特性可能与子宫内膜异位症的发病机理有关。

目的

为了系统地复习有关vit D代谢成分与子宫内膜异位之间关联的文献。

材料和方法

对Medline和Cochrane Central数据库中发表的文献进行了系统的综述，以各种语言发表的有关人类的原始研究文章。

结果

系统评价包括二十一项研究。其中，有12个研究了子宫内膜异位与vit D代谢产物的关系，八个与vit D结合蛋白（VDBP），三个与VDR多态性，两个与vit D调节酶之间的关系。现有文献出版物的结果之间存在差异。

结论

这是系统性的尝试，旨在收集，评估和介绍有关vit D与子宫内膜异位症之间关联的已知数据。考虑到本研究的异质性和多样性，需要更多的研究来阐明vit D与子宫内膜异位之间的关联。