Abstract

Despite major advances in polymer chemistry, cotton still remains the principal textile component in the global pharmaceutical industry owing to its intrinsic strength, thermal stability, biocompatibility, and pleasant texture. Nevertheless, the hydrophilic nature of cotton requires the development of strategies for the incorporation of hydrophobic functional molecules into the fabric for controlled-release applications. To address this issue, we designed biodegradable crosslinked poly(β-amino ester) (PBAE) coatings as reservoirs for the incorporation of small hydrophobic molecules and studied their release profiles under physiological conditions. Two PBAEs with different hydrophobic and degradation properties were prepared and crosslinked to cotton fabrics in the presence of azulene, which served as a model hydrophobic, active material. Optimization of the crosslinking process in terms of UV curing time and the amount of solvent revealed that curing time of 15 min using 0.5 mL of chloroform was the optimal crosslinking condition. The coatings were characterized by FTIR, XPS, and SEM as well as TGA and DSC analyses. Sustained release of azulene was observed, and there was a correlation between azulene delivery rates and the hydrophobicity of the coating. These results provide a potentially useful platform for the rational design of cotton-based controlled-release systems for bioactive molecule delivery applications.

Graphic abstract

中文翻译：

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可生物降解的聚合物涂层，可控制棉织物中疏水功能分子的释放

摘要

尽管聚合物化学领域取得了重大进步，但由于其固有的强度，热稳定性，生物相容性和令人愉悦的质感，棉花仍然仍然是全球制药行业中主要的纺织品成分。然而，棉花的亲水性要求开发用于将疏水性功能分子掺入到织物中以用于控释应用的策略。为了解决这个问题，我们设计了可生物降解的交联聚（β-氨基酯（PBAE）涂层作为小疏水分子掺入的储库，并研究了它们在生理条件下的释放曲线。制备了两种具有不同疏水和降解特性的PBAE，并在存在偶氮的情况下将其交联到棉织物上。在紫外线固化时间和溶剂量方面优化了交联过程，发现使用0.5 mL氯仿的15分钟固化时间是最佳的交联条件。通过FTIR，XPS和SEM以及TGA和DSC分析来表征涂层。观察到a青的缓释，并且a青的输送速率和涂层的疏水性之间存在相关性。

图形摘要