Nanomedicine is a rapidly growing and promising field to combat cancer. This study was aimed to systematically review the original published articles to evaluate the efficacy of biologically synthesized silver nanoparticles (AgNPs) against cervical cancer cells through in vitro investigations. The articles were selected through the online databases, including Cochrane, Embase, Scopus, PubMed, Science Direct, ProQuest, and Web of Science for the articles published up to 31 August 2019. Sixty-five articles were found eligible to enter into our study. Our finding revealed that a vast 92.3% of articles stated the significant cytotoxicity of biogenic AgNPs against cervical cancer cells, while 7.7% of articles represented no cytotoxicity against cervical cancer cells. The proposed molecular mechanisms of anticancer activity of biogenic AgNPs against cervical cancer cells included the release of silver cations from AgNPs in the cell culture medium, generation of intracellular Reactive Oxygen Species (ROS), induction of apoptosis pathways, and DNA damage. This study provided significant preliminary evidence from the anticancer potential of biogenic AgNPs against cervical cancer cells. Future molecular studies will elucidate the exact molecular mechanisms of biogenic AgNPs-induced cytotoxicity in cervical cancer cells.

中文翻译：

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抗肿瘤生物银纳米材料可抗击宫颈癌：癌症治疗的新方法

纳米医学是对抗癌症的快速发展和有希望的领域。这项研究旨在系统地审查原始发表的文章，以通过体外研究评估生物合成的银纳米颗粒（AgNPs）对宫颈癌细胞的功效。这些文章是通过在线数据库选择的，包括Cochrane，Embase，Scopus，PubMed，Science Direct，ProQuest和Web of Science，这些文章截至2019年8月31日发表。发现有65篇文章符合我们的研究要求。我们的发现表明，有92.3％的文章指出生物型AgNP对宫颈癌细胞具有明显的细胞毒性，而7.7％的文章则没有针对宫颈癌细胞的细胞毒性。拟议的生物型AgNPs对宫颈癌细胞的抗癌活性的分子机制包括：从细胞培养基中的AgNPs中释放银阳离子，生成细胞内活性氧（ROS），诱导细胞凋亡途径和DNA损伤。这项研究提供了重要的初步证据，从生物型AgNPs对宫颈癌细胞的抗癌潜力。未来的分子研究将阐明生物型AgNPs诱导子宫颈癌细胞的细胞毒性的确切分子机制。这项研究提供了重要的初步证据，从生物型AgNPs对宫颈癌细胞的抗癌潜力。未来的分子研究将阐明生物型AgNPs诱导子宫颈癌细胞的细胞毒性的确切分子机制。这项研究提供了重要的初步证据，从生物型AgNPs对宫颈癌细胞的抗癌潜力。未来的分子研究将阐明生物型AgNPs诱导子宫颈癌细胞的细胞毒性的确切分子机制。