Lycopene was simultaneously extracted from tomato processing waste and size reduced into nano-ranges from 36 to 150 nm, via ultrasonic assisted nanoprecipitation technique. The effects of main processing parameters namely, organic to aqueous phase ratio, ultrasonic amplitude and time were evaluated on mean particle size, polydispersity (PDI) and lycopene content of produced nanodispersions, using response surface method based on central composite design. All studied parameters affected the selected responses significantly (p-value < 0.05). The studied characteristics’ changes were significantly (p-value < 0.05) fitted to second order polynomial regression models of studied independent parameters by quite high coefficients of determination (R² > 0.9). The most desirable lycopene nanodispersions with mean particle size of 66.3 nm, PDI of 0.245 and lycopene content of 52 mg/g waste, were produced at organic to aqueous phase ratio of 0.5, and ultrasonication for 20 min at amplitude of 70%. The resulted insignificant differences between experimental and predicted data, certified the suitability of suggested response surface models.

中文翻译：

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超声参数对番茄加工废料中番茄红素的同时提取和粒径减小的影响

从番茄加工废料中同时提取番茄红素，并通过超声辅助纳米沉淀技术将其尺寸缩小至36至150 nm的纳米范围。使用基于中心复合设计的响应面方法，评估了主要加工参数（有机相与水相之比，超声振幅和时间）对生产的纳米分散体的平均粒径，多分散度（PDI）和番茄红素含量的影响。所有研究的参数均显着影响所选的响应（p值<0.05）。通过相当高的确定系数（R ²），将所研究特征的变化显着（p值<0.05）拟合至所研究独立参数的二阶多项式回归模型。 > 0.9）。最理想的番茄红素纳米分散体的平均粒径为66.3 nm，PDI为0.245，番茄红素含量为52 mg / g废料，在有机相与水相之比为0.5的情况下，以70％的振幅超声处理20分钟。实验数据和预测数据之间的差异不明显，证明了建议的响应面模型的适用性。