Rice bran hydrolysates contain highly nutritional proteins and beneficial phytochemicals. Sang-Yod rice bran hydrolysates (SRH) extracted from red pigmented rice is a rich source of nutrients and phenolic compounds. The present study evaluated the antihypertensive effect of SRH and its safety in Sprague-Dawley rats. Hypertension was induced in male rats by administration of L-NAME (50 mg/kg/day) in drinking water for three weeks, and the antihypertensive effect of SRH was evaluated. Treatment of SRH (250 or 500 mg/kg) significantly reduced arterial blood pressure and improved hemodynamic parameters. The antihypertensive effect was associated with decreased oxidative stress, suppressed p47 phox NADPH oxidase expression, increased nitric oxide bioavailability and decreased angiotensin II level and ACE activity. The SRH was shown to be safe after feeding male and female rats with a rodent diet containing 1.5% SRH for 90 days. Overall, these findings suggest that SRH is safe and may help to prevent hypertension.

中文翻译：

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桑叶米米糠水解物的降压作用及安全性评价

米糠水解物含有高营养蛋白质和有益的植物化学物质。从红色大米中提取的 Sang-Yod 米糠水解物 (SRH) 是营养物质和酚类化合物的丰富来源。本研究评估了 SRH 的抗高血压作用及其对 Sprague-Dawley 大鼠的安全性。通过在饮用水中施用 L-NAME (50 mg/kg/day) 三周，在雄性大鼠中诱发高血压，并评估 SRH 的抗高血压作用。SRH（250 或 500 mg/kg）的治疗显着降低了动脉血压并改善了血液动力学参数。抗高血压作用与减少氧化应激、抑制 p47 phox NADPH 氧化酶表达、增加一氧化氮生物利用度以及降低血管紧张素 II 水平和 ACE 活性有关。在用含有 1.5% SRH 的啮齿动物饮食喂养雄性和雌性大鼠 90 天后，SRH 被证明是安全的。总体而言，这些发现表明 SRH 是安全的，可能有助于预防高血压。