Abstract—We studied lipid peroxidation and measured the products of lipid peroxidation (LPO) together with the indices of the antioxidant system (AOS) in the blood of patients with epilepsy of various severities in the South Kazakhstan region of Kazakhstan. We examined 95 epileptic patients, including 35 patients with 3 seizure attacks per year, 30 patients with up to 12 seizure attacks per year, and 30 patients with more than 12 seizure attacks per year, that is, low, moderate, and severe levels of epilepsy, respectively, and 30 healthy men. We measured LPO products with simultaneous estimation of activity of superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPO) as well as antiradical (ARA) and antioxidant activity (AOA) in biological fluids. We also studied non-enzymatic antioxidant indices, such as the contents of α-tocopherol and SH-groups depending on epilepsy severity. We found that the content of LPO products in red blood cells and the deficit of the mechanisms of antioxidant defense increased depending on the severity of epilepsy in patients. In parallel to the increase in the level of lipid peroxides, lipid oxidizability was also enhanced in the blood of epileptic patients. Insufficiency of α-tocopherol was associated with decreased activity of SOD, AOA, and ARA in the body of patients. This complex study indicates that in epilepsy accumulation of lipid peroxides in the blood and a decrease in the activity of the AOS in the body occur. The expression of these processes directly depends on the severity of epilepsy.

中文翻译：

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癫痫患者血液中的脂质过氧化和抗氧化系统

摘要—我们研究了脂质过氧化作用，并在哈萨克斯坦南部哈萨克斯坦地区患有各种严重程度的癫痫患者的血液中测量了脂质过氧化作用（LPO）的产物以及抗氧化系统（AOS）的指数。我们检查了95例癫痫患者，其中35例每年发作3次，30例每年发作12次，30例每年发作12次以上，即低，中和重度癫痫发作癫痫病和30名健康男性。我们测量了LPO产品，同时估计了生物流体中的超氧化物歧化酶（SOD），谷胱甘肽还原酶（GR），谷胱甘肽过氧化物酶（GPO）以及抗自由基（ARA）和抗氧化活性（AOA）的活性。我们还研究了非酶类抗氧化剂指标，如α-生育酚和SH基团的含量取决于癫痫的严重程度。我们发现，红细胞中LPO产物的含量和抗氧化防御机制的缺陷取决于患者癫痫的严重程度而增加。与脂质过氧化物水平的增加同时，癫痫患者血液中脂质的氧化能力也得到增强。α-生育酚不足与患者体内SOD，AOA和ARA活性降低有关。这项复杂的研究表明，在癫痫病中，血液中脂质过氧化物的蓄积和体内AOS活性的降低会发生。这些过程的表达直接取决于癫痫的严重程度。我们发现，红细胞中LPO产物的含量和抗氧化防御机制的缺陷取决于患者癫痫的严重程度而增加。与脂质过氧化物水平的增加同时，癫痫患者血液中脂质的氧化能力也得到增强。α-生育酚不足与患者体内SOD，AOA和ARA活性降低有关。这项复杂的研究表明，在癫痫病中，血液中脂质过氧化物的积累和体内AOS活性的降低会发生。这些过程的表达直接取决于癫痫的严重程度。我们发现，红细胞中LPO产物的含量和抗氧化防御机制的缺陷取决于患者癫痫的严重程度而增加。与脂质过氧化物水平的增加同时，癫痫患者血液中脂质的氧化能力也得到增强。α-生育酚不足与患者体内SOD，AOA和ARA活性降低有关。这项复杂的研究表明，在癫痫病中，血液中脂质过氧化物的积累和体内AOS活性的降低会发生。这些过程的表达直接取决于癫痫的严重程度。癫痫患者血液中脂质的氧化能力也得到增强。α-生育酚不足与患者体内SOD，AOA和ARA活性降低有关。这项复杂的研究表明，在癫痫病中，血液中脂质过氧化物的积累和体内AOS活性的降低会发生。这些过程的表达直接取决于癫痫的严重程度。癫痫患者血液中脂质的氧化能力也得到增强。α-生育酚不足与患者体内SOD，AOA和ARA活性降低有关。这项复杂的研究表明，在癫痫病中，血液中脂质过氧化物的蓄积和体内AOS活性的降低会发生。这些过程的表达直接取决于癫痫的严重程度。