A 4.5-year-old cow showing neurological signs consistent with predictors of bovine spongiform encephalopathy (BSE) was investigated as a potential BSE-suspect case and proved to be negative. Macroscopic analysis revealed a tan neoplastic mass growing along the leptomeninges of the caudal brain and extending into the third (III) ventricle without significantly involving the neuroparenchyma. Pathological features (uniform round hyperchromatic neoplastic cells embedded in abundant myxoid matrix, microcysts, microvascular proliferation) and diffuse Olig2 expression were most consistent with diffuse high-grade leptomeningeal oligodendrogliomatosis. In line with former reports of extensive leptomeningeal involvement in bovine oligodendroglioma, this report suggests that bovine oligodendroglial tumors have a strong propensity to grow within the leptomeningeal space. In addition, it indicates that Olig2 is a useful marker to confirm glial lineage in formalin-fixed, paraffin-embedded bovine tissue.

一个4.5岁的母牛表现出与牛海绵状脑病（BSE）的预测指标一致的神经系统症状，被调查为可能的BSE可疑病例，并被证实为阴性。宏观分析显示，棕褐色的肿瘤性肿块沿尾脑的软脑膜生长，并延伸到第三（III）脑室，而没有明显累及神经实质。病理特征（均匀的圆形增生性赘生性细胞包埋在丰富的类胶质基质中，微囊肿，微血管增生）和弥散性Olig2表达与弥散性高级别软脑膜少突胶质瘤病最一致。与以前有关牛少神经胶质瘤广泛累及软脑膜的报道一致，该报告表明，牛少突胶质细胞瘤在脑膜神经间隙内有很强的生长倾向。另外，它表明Olig2是确认福尔马林固定，石蜡包埋的牛组织中神经胶质谱系的有用标记。