Bloodstream infections remain a leading cause of death worldwide, despite advances in critical care and understanding of the pathophysiology and treatment strategies. No specific biomarkers or therapy are available for these conditions. Neutrophils play a critical role in controlling infection and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated diagnostic biomarkers involved neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically predict the outcome of sepsis.

中文翻译：

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中性粒细胞在血液感染中的诊断作用。

尽管重症监护以及对病理生理学和治疗策略的理解有所提高，但血流感染仍是全球范围内死亡的主要原因。没有针对这些情况的特定生物标志物或疗法。中性粒细胞在控制感染中起着至关重要的作用，这表明败血症期间它们的迁移和抗菌活性受到损害，这会导致免疫反应失调。最近的研究进一步表明，中性粒细胞迁移和抗菌功能受损的中断或逆转可改善动物模型中败血症的发生。在这篇综述中，我们提供了败血症中涉及嗜中性粒细胞的相关诊断生物标志物的概述，并讨论了嗜中性粒细胞作为特异性预测败血症结果的靶标的潜力。