Hematopoietic stem cells (HSCs) produce new blood cells everyday throughout life, which is maintained by the self-renewal and differentiation ability of HSCs. This is not controlled by the HSCs alone, but rather by the complex and exquisite microenvironment surrounding the HSCs, which is called the bone marrow niche and consists of various bone marrow cells, growth factors, and cytokines. It is essential to understand the characteristic role of the stem cell niche and the growth factors in the niche formation. In this review, we describe the role of the bone marrow niche and factors for niche homeostasis, and also summarize the latest research related to stem cell niche.

中文翻译：

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生长因子在造血干细胞生态位中的作用。

造血干细胞（HSC）终生每天都会产生新的血细胞，这是由HSC的自我更新和分化能力所维持的。这不是仅由HSC控制，而是由HSC周围复杂而精致的微环境控制，这种环境称为骨髓生境，由各种骨髓细胞，生长因子和细胞因子组成。必须了解干细胞生态位的特征性作用以及生长因子在生态位形成中的作用。在这篇综述中，我们描述了骨髓生态位的作用和生态位稳态的因素，并总结了与干细胞生态位有关的最新研究。