Abstract

Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area, good biocompatibility, easy fabrication and surface modification. In particular, organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs, which enables hybrid nanofibers to serve as desired platform for drug delivery and tissue engineering applications. This review summarizes the recent progresses in the preparation, performances and applications of hybrid nanofibers as drug delivery vectors for antibacterial and antitumor therapy, and as nanofibrous scaffolds for bone tissue engineering or other types of tissue engineering applications. Nanofibers doped with various types of inorganic nanoparticles (e.g., halloysite, laponite^®, nano-hydroxyapatite, attapulgite, carbon nanotubes, and graphene, etc.) are introduced and summarized in detail. Future perspectives are also briefly discussed.

Graphic Abstract

中文翻译：

---

用于药物递送和组织工程应用的电纺有机/无机杂化纳米纤维的构建

摘要

电纺纳米纤维具有比表面积大，生物相容性好，易于制造和表面改性的优点，在生物医学应用中具有巨大潜力。特别地，有机/无机杂化纳米纤维表现出增强的机械性能以及包封药物的长期持续释放或控释特性，这使得杂化纳米纤维能够用作药物递送和组织工程应用的所需平台。这篇综述总结了混合纳米纤维的制备，性能和应用的最新进展，所述混合纳米纤维作为用于抗菌和抗肿瘤治疗的药物递送载体，以及作为用于骨组织工程或其他类型组织工程应用的纳米纤维支架。掺杂了各种类型的无机纳米粒子（例如，埃洛石，^®，纳米羟基磷灰石，绿坡缕石，碳纳米管和石墨烯等）进行了介绍和详细总结。还简要讨论了未来的观点。

图形摘要